An innovative CRISPR-Cas12f-based activator system may hold significant potential in the future of gene therapy and biological research, suggest researchers of a new study. The study highlights the ...

Revvity's Dharmacon All-in-one lentiviral platform has expanded to include whole-genome library options for CRISPR knockout (CRISPRko), CRISPR interference (CRISPRi), and CRISPR activation (CRISPRa).

CRISPR activation restores FLNC expression and reverses cardiac electrical abnormalities in mice carrying a truncating variant of the gene • The study was led by researchers at the Centro Nacional de ...

CRISPR-Cas9 has been widely adapted for use in transcriptional modulation and epigenetic engineering with deactivated Cas9 (dCas9) systems to enable CRISPR interference (CRISPRi) and CRISPR activation ...

The onset and aggressiveness of cancer are related to the abnormal behavior of certain genes, known as oncogenes. The best-known of these alterations is mutation, but it is not the only one. Sometimes ...

Researchers at Texas A&M are pairing a widely used ingredient with advanced medical technology to develop new treatments for ...

In a recent study, researchers manipulated cellular proteins that control genes in aged mice. Experimental results showed their livers were rejuvenated to younger states. This work shows promise as a ...

Researchers used CRISPR gene editing to selectively kill cancer cells with amplified oncogenes. In animal and cellular models ...