Lung cancer is the leading cause of cancer-related death in industrialised countries. The majority of patients with lung cancer have incurable advanced disease with very poor therapeutic options, so ...

However, the measurement of sIL-2R is simple compared to the complex story behind this biomarker that has become so central to the study of immune-mediated disease. Why measure soluble interleukin-2 ...

Here, we summarize the cellular sources of IL-9, focusing principally on T cells. We also describe the main targets of IL-9 in vivo and discuss the downstream effects of IL-9-induced signalling on ...

The cytokine profile (including key cytokine receptors as denoted by R), the effector cell type that is activated, and the corresponding types of infections are shown for each Th subgroup. The ...

Crohn's disease is associated with excess cytokine activity mediated by type 1 helper T (Th1) cells. Interleukin-12 is a key cytokine that initiates Th1-mediated inflammatory responses. This ...

Department of Medicine, University of Toronto, Women's College Hospital, and co-authors have found biologics targeting interleukin (IL)-12, IL-23, or IL-17 were associated with a lower rate of serious ...

Interleukin-6 (IL-6) is a pleiotropic cytokine secreted by T cells and macrophages to activate immune responses during infection or after trauma. IL-6 plays an important role in a number of bodily ...

Vunakizumab, an interleukin-17 inhibitor, shows improved efficacy over placebo in treating active psoriatic arthritis at week ...

Interleukin (IL)-1 is a prototypic proinflammatory cytokine. It is produced by numerous cell types (i.e., macrophages, synoviocytes, endothelial cells, chondrocytes, osteoclasts) and is found in ...

Skin wounds from ischemia-reperfusion injuries -- tissue damage caused by blood returning to tissues after a period of oxygen deprivation -- may not heal appropriately in some patients, owing to ...

However, imbalances of IL-6 — too much or too little — can cause disease, even in the absence of infection. Excess IL-6 is central to the pathogenesis of inflammatory reactions like rheumatoid disease ...

Clinical Utility of Microarray-Based Gene Expression Profiling in the Diagnosis and Subclassification of Leukemia: Report From the International Microarray Innovations in Leukemia Study Group Plasma ...