In order for HIV to replicate, the viral genome must enter into the cell nucleus and integrate into the host cell chromosome. Previous work suggests that the entry proceeds through nuclear pore ...

A computational model of the more than 26 million atoms in a DNA-packed viral capsid expands our understanding of virus structure and DNA dynamics, insights that could provide new research avenues and ...

UNSW medical researcher Dr David Jacques and his team have discovered how the human immunodeficiency virus (HIV) breaches the cell nucleus to establish infection, a finding that has implications ...

The FDA granted priority review, with a decision expected by June 19, 2025. LEN represents a novel class of HIV therapies by targeting the viral capsid, a multifunctional protein essential for HIV ...

A new combination of microscopy methods has revealed exquisite detail of the virus assembly process used by herpes simplex virus during replication. The research, published today as a Reviewed ...

Assembly of HIV-1, which causes AIDS, takes place on the inner plasma membrane leaflet of infected cells, a geometric building process that creates hexamers out of trimers of the viral Gag protein, as ...

Yet certain details of that virion assembly have been lacking for four decades. In a study published in the journal Proceedings of the National Academy of Sciences, Jamil Saad, Ph.D., and colleagues ...

New research from the University of Minnesota School of Dentistry and Masonic Cancer Center is providing important new insights into the structure of a human virus that causes blood cancer. In their ...

UNSW Sydney medical scientists have cracked a mystery whose solution has long eluded researchers. UNSW Sydney medical scientists have cracked a mystery whose solution has long eluded researchers. UNSW ...

Gilead Sciences announced a significant milestone: the U.S. FDA accepted their New Drug Applications (NDAs) for lenacapavir (LEN), a groundbreaking twice-yearly injectable HIV-1 capsid inhibitor for ...