May 10, 2024 · Authors note that tumors likely employ a variety of strategies to evade immune detection. But the discovery could lead to a new approach for targeted cancer therapies.

The present study was initiated by comparing publicly available transcription profiles of tumor tissues from responsive and resistant ICB-treated patients across various cancer types.

Identified as a hallmark in 2011, ten years after the seminal “The Hallmarks of Cancer” paper was published in Cell, the concept reflects the critical role the immune system plays in both suppressing …

Mar 13, 2025 · However, tumor cells have developed sophisticated ways to evade detection, including hijacking the immune system’s brake mechanism, known as immune checkpoints.

Research led by the Chiba Cancer Center Research Institute in Japan has discovered a surprising way cancer evades the immune system. It essentially hacks the immune cells, transferring its...

Discover how cancer cells bypass immune defenses and explore innovative strategies to combat the disease through scientific insights and therapeutic approaches.

Oct 1, 2020 · Interactions between immune checkpoints (ICs) and their ligands negatively regulate T cell activation pathways involved in physiological immune respon…

Yet, tumors employ various mechanisms to evade or counteract attack by immune response components. Some of these mechanisms involve changes in the manifestation of tumor cells, others …

Jan 22, 2016 · Normally, Drake explains, these checkpoints function to protect the body from auto-immune attack; "but in cancer, tumors hijack those pathways to protect themselves, instead."

Mar 22, 2024 · In summary, EV PD-L1 affects both immune cells and tumor cells, leading to the suppression of anti-tumor immunity and promotion of tumor progression. These processes ultimately …