Experimentally, targeting MYC and the MYC pathway seems to both affect cancer cells and restore antitumour immunity. The evidence of MYC as a grand orchestrator provides further impetus to …

In B cells, Myc acts as a classical oncogene by regulating a number of pro-proliferative and anti-apoptotic pathways, this also includes tuning of BCR signaling and CD40 signaling in regulation of …

Jul 21, 2025 · Learn how the Myc protein acts as a fundamental regulator of cell growth and how its dysregulation becomes a central driver of cancer development.

Feb 19, 2025 · This Review provides an overview of the various strategies to inhibit MYC, focusing on the most recently described inhibitors and those that have reached clinical trials.

The discovery of the MYC oncogene was a major milestone along the road leading to our current understanding of genetic alterations in cancer and how transcription contributes to tumorigenesis.

Mar 14, 2025 · The main apoptotic pathways controlled by MYC, its contribution to tumor plasticity, and its interactions with other oncogenes and tumor suppressors will be discussed.

Aug 9, 2021 · Indeed, in response to PDGF, Src activates a signaling pathway known as the Src pathway that culminates in the transcription of MYC. Src phosphorylates Vav2 mediator, resulting in …

MYC produces the transcription factor Myc, which dimerizes with Max and bind target DNA sequences or E-boxes (with the sequence 5′-CANNTG-3′) to regulate transcription of genes involved in cell …

MYC produces the transcription factor Myc, which dimerizes with Max and binds target DNA sequences or E boxes (with the sequence 5′-CANNTG-3′) to regulate transcription of genes involved in cell …

Recent evidence strongly suggests that Myc-dependent metabolic reprogramming is critical for tumorigenesis, which could be attenuated by targeting specific metabolic pathways using small drug …