The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity.

Aug 23, 2023 · The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell cycle progression.

The PI3K/AKT/mTOR pathway is defined as a crucial signaling pathway that regulates cell growth and proliferation, frequently dysregulated in cancer, contributing to endocrine resistance and poor …

The PI3K/Akt/mTOR pathway is an internal communications network within cells that regulates the cell cycle. Its proper function is tied to normal cellular processes like growth and survival, while its …

5 days ago · Emerging evidence reveals that the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway acts as a pivotal regulator of ABC transporters, …

Nov 5, 2023 · In this review, we outline the role of the PI3K/Akt/mTOR signaling pathway in blood malignancies’ cells and gather information on the inhibitors of this pathway that might provide a novel …

Jul 30, 2025 · This review comprehensively outlines the oncogenic mechanisms governed by the PI3K/AKT/mTOR pathway, including its regulation of epithelial–mesenchymal transition, autophagy, …

The PI3K-AKT-mTOR pathway is like a bustling highway within our cells, orchestrating a flurry of activity that fuels cellular metabolism, growth, and survival. This signaling cascade plays a pivotal role in …

Aug 4, 2025 · Learn about the PI3K/Akt/mTOR signaling pathway, a central cellular regulator essential for health and a significant target in disease.

This article presents an overview of the PI3K/Akt/mTOR signaling pathway. As a central regulator of cell growth, protein translation, survival, and metabolism, activation of this signaling pathway contributes …